Interferons and interferon inducers

by N. B. Finter

Publisher: North-Holland in Amsterdam, London

Written in English
Published: Downloads: 304
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Edition Notes

Previous ed. published as "Interferons. Amsterdam:North -Holland, 1966.

Statementedited by N.B. Finter.
SeriesFrontiers of biology, vol. 2
ID Numbers
Open LibraryOL20377748M

interferon (ĭn'tərfēr`ŏn), any of a group of proteins produced by cells in the body in response to an attack by a virus virus, parasite with a noncellular structure composed mainly of nucleic acid within a protein coat. Most viruses are too small (–2, Angstrom units) to be seen with the light microscope and thus must be studied by electron microscopes. At long last, the first book to cover all important areas of interferon science in one volume. Top scientists, including many pioneers in the field, highlight the role of interferons as research tools and as therapeutic agents in clinical applications. Edited by an experienced interferonologist. Interferons alfa-2a and -2b differ at amino acid position 23; alfa-2a has a lysine in that position, while -2b has an arginine at that position. Compared to other interferon alfa subtypes, interferons alfa-2a and -2b both have a deletion at position 44 in the amino acid sequence. Interferon alfa-2b is commonly prescribed in a kit with ribavirin. Pharmacology of Interferon. Interferon. Natural Interferons. Man Made Interferons (Recombinant) Interferon Basics Interferons play an important role in the first line of defense against viral infections Interferons are part of the non-specific immune system Interferons are made by cells in response to an appropriate stimulus. Types on Interferon alpha (leukocyte interferon) produced by virus.

Participants can join the Conference (Webinar) each month on related contents. Submit your Paper / Abstracts to present at Webinar before the end of each month at: [email protected] as attachment. Faculty and research students can present the papers. The participants will be recognized with Certificates for paper presentation. The conference covers all aspects of subject.   interferon 1. Abdul Mannan M. Phil Scholar Deptt. Of Pathobiology FVS, BZU Multan 2. Naturally occurring proteins and glycoproteins Secreted by eukaryotoc cells in response to viral inections, tumors and other biological inducers Structurally, they are part of the helical cytokine family which are characterized by an amino acid chain that is amino acids long. The authors have studied the antiviral effect of certain interferon inducers in mice infected with vaccinia virus by injection into the tail vein. A number of materials injected intraperitoneally or intravenously 1 or 8 days before infection caused a significant reduction in the number of lesions. They included bacteria (Brucella abortus, Proteus rettgeri, Escherichia coil), viruses (Sindbis, Cited by:   Interferons are broken down into recombinant versions of a specific interferon subtype and purified blends of natural human interferon. & many of these are in clinical use and are given intramuscularly or subcutaneously Recombinant forms of alpha interferon include: • Alpha-2a drug name Roferon • Alpha-2b drug name Intron A • Alpha-n1.

The loss of biological activity of interferons is prevented or reduced by the addition of soluble lanthanide or calcium salts. USA - Interferon stabilization - Google Patents Interferon stabilization Download PDF Info Publication number USA. USA US06/ Title: Synthetic and Natural Immunomodulators Acting as Interferon Inducers VOLUME: 15 ISSUE: 11 Author(s):Dmytro S. Silin, Oksana V. Lyubomska, Feliks I. Ershov, Valeriy M. Frolov and Galyna A. Kutsyna Affiliation:Laboratory of Molecular Virology, Medical and Biology Center, School of Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.

Interferons and interferon inducers by N. B. Finter Download PDF EPUB FB2

Interferons, Interferon Inducers, and Interferon-Ribavirin in Treatment of Flavivirus-Induced Encephalitis in Mice Pieter Leyssen, 1 Christian Drosten, 2 Marcus Paning, 2 Nathalie Charlier, 1 Jan Paeshuyse, 1 Erik De Clercq, 1 and Johan Neyts 1, *Cited by: Additional Physical Format: Online version: Finter, Norman B.

Interferons and interferon inducers. Amsterdam, North-Holland Pub. Co.; New York, American Elsevier Pub. Clinical application of interferons and their inducers. New York: Dekker, © (OCoLC) Online version: Clinical application of interferons and their inducers.

New York: Dekker, © (OCoLC) Document Type: Book: All Authors / Contributors: Dale A Stringfellow. Interferons and Interferon Inducers (Frontiers of Biology) [Finter, N.

(ed).] on *FREE* shipping on qualifying offers. Interferons and Interferon Inducers (Frontiers of Biology)Author: N. (ed). Finter. Interferons are proteins that are part of your natural defenses. They tell your immune system that germs or cancer cells are in your body. And they trigger killer immune cells to fight those : Stephanie Watson.

Type I interferons (a group consisting of interferons α/β/ω and τ) and type II (interferon-γ) are described for their role in immunologic reactions, association with various diseases and their therapeutic potential.

Type III interferons (interferon-λ), also named interleukin and. The use of interferons and interferon inducers to treat human viral and neoplastic diseases is currently under intensive investigation. Considerable attention is thus focused on Interferons and interferon inducers book structure and.

Interferon-a (a family of about 20 related proteins) and interferon-b are particularly potent as antiviral agents. They are not expressed in normal cells, but viral infection of a cell causes interferons to be made and released from the cell (that cell will often eventually die as a result of the infection).

Interferon Type I. Type I interferon (IFNα/β) is a cytokine that provides one of the first lines of host defense against virus infection (Biron and Sen, ) and can rapidly protect cell culture against infection by all FMDV serotypes (Chinsangaram et al., ; Grubman and Baxt, ).

xviii, p. ; 24 cm. --Revised ed. published in under title: Interferons and interferon inducers Bibliography: p. []Pages: Interferon (3 M IU × 3 times weekly for ∼ weeks) and rituximab ( mg per lesion, 3 times weekly for 1 week, possibly repeated 4 weeks later) are sometimes used in the management of.

The Interferons. I nterferons (IFNs) are naturally secreted glycoproteins produced by almost every cell type as a mechanism of host defense in response to microbial attack (Rees ) and tumor cells (Young ).They were coined “interferons”, because they protected cells by interfering with viral infection (Nagano and others ; Lindenmann and Isaacs ).Cited by:   Purchase Interferons - 1st Edition.

Print Book & E-Book. ISBNBook Edition: 1. The first inducer of interferon to be discovered was a virus, influenza (Isaacs and Lindenmann, ).

In the several years following this discovery, it became apparent that practically each cell-virus interaction attempted was capable of elaborating an interferon.

Title: Antiviral Agents. (Book Reviews: Interferons and Interferon Inducers) Book Authors: Finter, N. Review Author: Morahan, Page S. Publication. The Interferon Story is a richly rewarding book written for ordinary people without a basic knowledge of biology or medicine.

It can be read as a thriller describing the struggle of scientists against the most feared diseases of mankind.

Overall, interest in the medical application of interferons and inducers reached its lowest point in the. Find patient medical information for Interferon Alfa-2B Injection on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

Of all published articles, the following were the most read within the past 12 months. The book opens with a chapter that comprehensively reviews the antiviral effects of extracellular double-stranded RNA, the viral toxin. This is followed by chapters that review the properties of type I and type III interferons, and the role of interferon-stimulated genes.

The next five chapters are devoted to understanding the diverse strategies used by clinically relevant human viruses to.

Interferons also activate other cells that serve as part of the immune system and destroy invading pathogens. Interferons are classed as: alpha (from white cells), beta (from fibroblasts) and gamma (from lymphocytes).

Interferons enhance the immune system in many ways so can be used to treat different conditions involving the immune system. The Interferon System: an overview. An overview on the Interferon system. Abstract Interferons are a family of related and naturally occurring signal proteins by mitogens in general.

However, the crucial point is that all these inducers trigger the production of alpha interferon by. Interferon, any of several related proteins that are produced by the body’s cells as a defensive response to viruses. They are important modulators of the immune response.

interferon Three vials filled with human leukocyte interferon. National Institutes of Health. Read. This chapter aims to describe and review the main important cytokines types (notably interferons), including their biological activities, functions and structures.

As a high number of molecules are available, synthesis of the most important cytokines, including tumor factor necrosis, interferons and interleukins will be presented.

Here we also describe the relationships between those cytokines Author: Vinicius L. Ferreira, Helena H.L. Borba, Aline de F.

Bonetti, Leticia t, Roberto Pontarolo. Interferons: cell signalling, immune modulation, antiviral responses and virus countermeasures S. Goodbourn,1 L. Didcock2 and R. Randall2 1 Department of Biochemistry and Immunology, St George’s Hospital Medical School, University of London, London SW17 0RE, UK 2 Biomolecular Sciences Building, North Haugh, University of St Andrews, Fife.

Two years ago, local application of interferon-stimulating double-stranded RNA was evaluated in the human respiratory tract for prophylactic effects against viruses, with only slightly beneficial r Cited by: 1.

Interferon alfa-2a is contraindicated in patients with autoimmune hepatitis and in patients with hepatic decompensation (Child-Pugh class B and C) before or during treatment. Interferon alfa-2a should not be used in the treatment of patients with visceral AIDS-related Kaposi's Sarcoma associated with rapidly progressive or life threatening disease.

Interferons: A Primer covers general information on interferon, including analysis, purification, production, properties, mechanism of action, and clinical uses. Organized into 10 chapters, the book starts with a short history of interferon’s discovery by Isaacs and Lindenmann, followed by topics on assays for interferon, such as factors Book Edition: 1.

Interferons refer to glycoproteins which are synthesized by different cells in reaction to specific chemical inducers, immune stimulation, and viral infection. Interferon seems to act in a paracrine ability in the immune system, with an extensive range of.

(Second of Three Parts) Properties of Interferon Cells from several different classes of animals, including teleost fishes, have been shown to produce interferon.4, One interesting biologic pro Cited by: Interferon has also been shown to have some antitumor properties.

There are three known classes of interferons: alpha- beta- and gamma-interferons. Although they were discovered in the s, the medical use of interferons was impractical until the recombinant DNA techniques of genetic engineering genetic engineering.

The interferons have different characteristics that could be used to distinguish them (e.g. pH stability and activity in the presence of SDS) but currently they are identified by using specific antibodies to the interferons.

b) Inducers of Interferons - Normal cells do not contain preformed IFN nor do they secret interferon constitutively.Host cells have multiple PRRs including TLRs, RIG-I, MDA5 that recognize viral products.

triggers signaling cascade w phosphorylation, kinases -> phosphorylation of latent transcription factors (TF) (always produced) in the cytoplasm, IRF3/7 and NFκB*. TF translocate to the nucleus, bind promoter of IFN-β*. Other TF bind, chromatin remodel, and change promoter structure.Interferon Interferon and Interferon Inducers.

Clinical Applications. DALE A. STRINGFELLOW, Ed. Dekker, NewYork, xii, pp., illus. $ Modem Pharmacology-Toxicology, vol. The first flowering ofinterferon stud-ies occurred in the late '50's and early '60's.

Duringthis time the basic biologi-cal properties ofinterferons were eluci.